于 捷 神经药理学，助理研究员

   Tel: 15858266083 E-mail: yujie@zcmu.edu.cn

  一、个人简历：

于捷，男，助理研究员，美国亚利桑那大学药理系博士后。博士毕业于浙江大学药学院，浙江大学神经科学研究所。研究方向：神经药理学，中药神经药理学。

二、承担或参与科研、教学教改等项目情况：

1、国家自然科学基金青年项目，81603088，组胺H3受体拮抗剂对II型复杂性区域疼痛综合征的镇痛作用及机制，2017/01-2019/12,17.3万元，在研，主持。

2、国家自然科学基金面上项目，81673623，低剂量雷公藤甲素抗颞叶癫痫作用的神经环路机制研究，2017/01-2020/12，73.8万元，在研，参与。

3、国家自然科学基金面上项目，81473187，TLR4受体在小鼠三叉神经损伤诱导的脊髓内中枢敏化的扩散中的作用及机制研究，2015/01-2018/12，65万元，已结题，参与。

三、代表性论文：

(1) Yu Jie#, Moutal# A, Dorame A, Bellampalli SS, Chefdeville A, Kanazawa I, Pham NYN, Park KD, Weimer JM, Khanna R*. Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission. Molcular Neurobiology. 2018, https://doi.org/10.1007/s12035-018-1445-6.

(2) Yu Jie#, Lu H#, Zhou J, Xie Z, Wen C, Xu Z*. Oral prednisolone versus non-steroidal anti-inflammatory drugs in the treatment of acute gout: a meta-analysis of randomized controlled trials. Inflammopharmacology. 2018 Jun;26(3):717-723.

(3) Jie Yu, Yingying Tang, Ranran Wang, Guodong Lou, Tingting Hu, Weiwei Hou, Jiaxing Yue, Hiroshi Ohtsu, Liyun Shi, Shihong Zhang*, Zhong Chen*. A critical time window for the analgesic effect of central histamine in the partial sciatic ligation model of neuropathic pain. Journal of Neuroinflammation. 2016; 13(1):163.

(4) Shihong Zhang#, Jie Yu#, Guodong Lou, Yingying Tang, Ranran Wang, Weiwei Hou, Zhong Chen*, Widespread pain sensitization after partial infraorbital nerve transection in MRL/MPJ mice, PAIN, 2016;157(3): 740-749.

(5) Jie Yu#, Qi Fang#, Gudong Lou, Wenting Shou, Jiaxing Yue, Yingying Tang, Weiwei Hou, Tianle Xu, Hiroshi Ohtsu, Shihong Zhang*, Zhong Chen*, Histamine Modulation of Acute Nociception Involves Regulation of Na(v)1.8 in Primary Afferent Neurons in Mice, CNS Neuroscience & Therapeutics, 2013;19(9): 649-658.

(6) Jie Yu#, Gudong Lou#, Jiaxing Yue, Yingying Tang, Weiwei Hou, Wenting Shou, Hiroshi Ohtsu, Shihong Zhang*, Zhong Chen*, Effects of histamine on spontaneous neuropathic pain induced by peripheral axotomy, Neuroscience Bulletin, 2013;29(3): 261-269.

(7) Khanna R, Yu J, Yang X, Moutal A, Chefdeville A, Gokhale V, Shuja Z, Chew LA, Bellampalli SS, Luo S, François-Moutal L, Serafini MJ, Ha T, Perez-Miller S, Park KD, Patwardhan AM, Streicher JM, Colecraft HM, Khanna MTargeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy. Pain. 2019 Jul; 160(7):1644-1661.

(8) Cai S, Bellampalli SS, Yu Jie, Li W, Ji Y, Wijeratne EMK, Dorame A, Luo S, Shan Z, Khanna M, Moutal A, Streicher JM, Gunatilaka AAL, Khanna R. (-)-Hardwickiic acid and Hautriwaic acid induce antinociception via blockade of tetrodotoxin-sensitive voltage-dependent sodium channels. ACS Chem Neurosci. 2018 Dec 7. doi: 10.1021/acschemneuro.8b00617.

(9) Wang X, Zu Y, Huang L, Yu Jie, Zhao H, Wen C, Chen Z, Xu Z. Treatment of rheumatoid arthritis with combination of methotrexate and Tripterygium wilfordii: A meta-analysis. Life Sci. 2017 Feb 15;171: 45-50.