徐家宝 病原生物学，讲师，

   Tel: 0571-86613613

   E-mail:Jiabao_xu @126.com

   一、个人简历：

徐家宝，女，毕业于南方医科大学病原生物学专业。研究方向：蚊媒传染病防治与控制，媒介生物流行病学、媒介分子生物学。

2013-2016赴美国加州大学欧文分校交流访问。现任广东省预防医学会媒介生物学及控制专业委员会委员。

二、承担或参与科研、教学教改等项目情况：

1．广东省自然科学基金白纹伊蚊杀虫剂抗性机理研究 2017.6.1-2020.5.31   （负责人）

2．中国博士后基金 筛选压力对白纹伊蚊杀虫剂抗性的影响及其分子机制研究2016.9.1-2018.8.31 （结题）  （负责人）

三、代表性论文

1. Xu J, Su X, Bonizzoni M, Zhong D, Li Y, Zhou G, Nguyen H, Tong S, Yan G, Chen XG. Comparative transcriptome analysis and RNA interference reveal CYP6A8 and SNPs related to pyrethroid resistance in Aedes albopictus. PLoS Negl Trop Dis. 2018 Nov 12;12(11):e0006828. doi: 10.1371/journal.pntd.0006828.

2. Xu J, Bonizzoni M, ZhongD, Zhou G, Cai S, Li Y, Wang X, Lo E, Lee R, Sheen R, Duan J, Yan G, Chen X. 2016. Multi-Country Survey Revealed Prevalent and Novel F1534S Mutation in Voltage-Gated Sodium Channel (VGSC) Gene in Aedes albopictus. PLoS Negl Trop Dis. 2016 4;10(5):e0004696. doi: 10.1371/journal.pntd.0004696.

3. Liu H, Xie L, Cheng P, Xu J, Huang X, Wang H, Song X, Liu L, Wang H, Kou J, Yan G, Chen XG, Gong M. Trends in insecticide resistance in Culex pipiens pallens over 20 years in Shandong, China. Parasit Vectors. 2019 Apr 11;12(1):167. doi: 10.1186/s13071-019-3416-9. PMID: 30975185; PMCID: PMC6460514.

4. Li Y, Xu J, Zhong D, Zhang H, Yang W, Zhou G, Su X, Wu Y, Wu K, Cai S, Yan G, Chen X. Evidence of increased multiple-resistance in urban Aedes albopictus populations. Parisite & Vectors. 2017.12.

5. Liu PW, Xu JB, Dong YQ, Chen XG, Gu JB. Use of a Recombinant Mosquito Densovirus As a Gene Delivery Vector for the Functional Analysis of Genes in Mosquito Larvae. J Vis Exp. 2017. (128). doi: 10.3791/56121.

6. Lo E, Nguyen K, Nguyen J, Hemming-Schroeder E, Xu J, Etemesi H, Githeko A, Yan, G. Plasmodium malariae Prevalence and csp gene diversity, Kenya, 2014 and 2015. Emerging Infectious Disease. 2017;23(4):601-610. doi: 10.3201/eid2304.161245.

7. Zhou Y, Liu Y, Yan H, Li Y, Zhang H, Xu J, Puthiyakunnon S, and Chen X. 2014. miR-281, an abundant midgut-specific miRNA of the vector mosquito Aedes albopictus enhances dengue virus replication. Parasit Vectors. 7: 488.

8. Liu Z, Zhou T, Lai Z, Zhang Z, Jia Z, Zhou G, Williams, T, Xu J, Gu J, Zhou X, Lin L, Yan G, Chen X. Vector competence of Aedes aegypti, Aedes albopictus and Culex quinquefasciatus for Zika virus, China. Emerging Infectious Disease. 2017;23(7):1085-1091. doi:10.3201/eid2307.161528.

9. Wang X, Liu T, Wu Y, Zhong D, Zhou G, Su X, Xu J, Sotero CF, Sadruddin AA, Wu K, Chen XG, Yan G. Bacterial microbiota assemblage in Aedes albopictus mosquitoes and its impacts on larval development. Mol Ecol. 2018 Jul;27(14):2972-2985. doi: 10.1111/mec.14732. Epub 2018 Jun 17. PMID: 29845688; PMCID: PMC6380897.

10. Bonizzoni M, Ochomo E, Dunn WA, Britton M, Afrane Y, Zhou G, Hartsel J, Lee MC, Xu J, Githeko A, Fass J, Yan G. RNA-seq analyses of changes in the Anopheles gambiae transcriptome associated with resistance to pyrethroids in Kenya: identification of candidate-resistance genes and candidate-resistance SNPs. Parasit Vectors. 2015 Sep 17;8:474. doi: 10.1186/s13071-015-1083-z. PMID: 26381877; PMCID: PMC4574070.